Wake Forest News

April 19, 2017
by Alicia Roberts  |  media@wfu.edu  |  336.758.5237

With beetroot juice before exercise, aging brains look ‘younger’

Drinking a beetroot juice supplement before working out makes the brain of older adults
perform more efficiently, mirroring the operations of a younger brain, according to a new
study by scientists at Wake Forest University.
“We knew, going in, that a number of studies had shown that exercise has positive
effects on the brain,” said W. Jack Rejeski, study co-author. “But what we showed in
this brief training study of hypertensive older adults was that, as compared to exercise
alone, adding a beet root juice supplement to exercise resulted in brain connectivity that
closely resembles what you see in younger adults.”
While continued work in this area is needed to replicate and extend these exciting
findings, they do suggest that what we eat as we age could be critically important to the
maintenance of our brain health and functional independence.
Rejeski is Thurman D. Kitchin Professor and Director of the Behavioral Medicine
Laboratory in the Department of Health & Exercise Science. The study, “Beet Root
Juice: An Ergogenic Aid for Exercise and the Aging Brain,” was published in the peer-
reviewed Journals of Gerontology: Medical Sciences. One of his former undergraduate
students, Meredith Petrie, was the lead author on the paper.

This is the first experiment to test the combined effects of exercise and beetroot juice on
functional brain networks in the motor cortex and secondary connections between the
motor cortex and the insula, which support mobility, Rejeski said.

The study included 26 men and women age 55 and older who did not exercise, had
high blood pressure, and took no more than two medications for high blood pressure.
Three times a week for six weeks, they drank a beetroot juice supplement called Beet-It
Sport Shot one hour before a moderately intense, 50-minute walk on a treadmill. Half
the participants received Beet-It containing 560 mg of nitrate; the others received a
placebo Beet-It with very little nitrate.

Beets contain a high level of dietary nitrate, which is converted to nitrite and then nitric
oxide (NO) when consumed. NO increases blood flow in the body, and multiple studies
have shown it can improve exercise performance in people of various ages.

“Nitric oxide is a really powerful molecule. It goes to the areas of the body
which are hypoxic, or needing oxygen, and the brain is a heavy feeder of
oxygen in your body.” Jack Rejeski

When you exercise, the brain’s somatomotor cortex, which processes information from
the muscles, sorts out the cues coming in from the body. Exercise should strengthen
the somatomotor cortex.

So, combining beetroot juice with exercise delivers even more oxygen to the brain and
creates an excellent environment for strengthening the somatomotor cortex. Post-
exercise analysis showed that, although the study groups has similar levels of nitrate
and nitrite in the blood before drinking the juice, the beetroot juice group had much
higher levels of nitrate and nitrite than the placebo group after exercise.

The study was supported by the Translational Science Center of Wake Forest and
received funding from the National Institutes of Health. The research team included
Paul J. Laurienti and Jonathan H. Burdette of the Department of Radiology; Anthony P.
Marsh of the Department of Health & Exercise Science; Swati Basu and Daniel B. Kim-
Shapiro of the Department of Physics; and James L. Norris of the Department of
Mathematics.